8號(hào)染色體計(jì)數(shù)探針

 廣州健侖生物科技?有限公司 

本司長(zhǎng)期供應(yīng)尼古?。商鎸帲z測(cè)試劑盒，其主要品牌包括美國(guó)NovaBios、廣州健侖、廣州創(chuàng)侖等進(jìn)口產(chǎn)品，國(guó)產(chǎn)產(chǎn)品，試劑盒的實(shí)驗(yàn)方法是膠體金方法。

我司還有很多熒光原位雜交系列檢測(cè)試劑盒以及各種FISH基因探針和染色體探針等，。

8號(hào)染色體計(jì)數(shù)探針

   本試劑盒主要用于8號(hào)染色體計(jì)數(shù)的檢測(cè)，里面包括即用型雜交液和DAPI復(fù)染劑。
本試劑盒僅供科研使用。

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 

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【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-3室

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在刑偵領(lǐng)域，死亡時(shí)間的確定是破案zui重要的線索之一，圍繞它展開的相關(guān)研究一直沒(méi)有停止。但是，現(xiàn)實(shí)沒(méi)有我們想得那么樂(lè)觀。專家表示，現(xiàn)在業(yè)內(nèi)還是用傳統(tǒng)方法居多，而以基因表達(dá)確定死亡時(shí)間，盡管法醫(yī)專家已經(jīng)研究了很多年，但仍停留在實(shí)驗(yàn)室，離真正應(yīng)用還有較長(zhǎng)的路要走。

一直沒(méi)有*方法

到目前為止，法醫(yī)學(xué)領(lǐng)域推斷死亡時(shí)間的技術(shù)手段，主要是依據(jù)尸體現(xiàn)象，如尸僵、尸斑、尸溫等，胃內(nèi)容的消化程度以及尸體周圍、植物的生長(zhǎng)變化規(guī)律等。“準(zhǔn)確推斷死亡時(shí)間是法醫(yī)學(xué)界*的難題，目前尚未有不受個(gè)體差異和死后變化影響的‘金指標(biāo)’可用于實(shí)際案件。”gongan部物證鑒定中心法醫(yī)病理?yè)p傷技術(shù)處副處長(zhǎng)何光龍說(shuō)。

從專業(yè)的角度講，根據(jù)尸體現(xiàn)象推斷死亡時(shí)間的方法多與統(tǒng)計(jì)學(xué)有關(guān)，也有相關(guān)的公式。但正如何光龍所說(shuō)，環(huán)境的溫濕度、死者的體格、死亡原因等各種因素都會(huì)造成死后變化的個(gè)體差異性，從而影響死亡時(shí)間推斷的準(zhǔn)確性。比如，通過(guò)尸溫變化來(lái)推斷早期死亡時(shí)間在目前案件中應(yīng)用較廣，但尸溫的變化受死者的胖瘦、衣著狀態(tài)、周圍環(huán)境的溫度變化等多因素干擾。相同環(huán)境下胖子的尸溫比瘦子的尸溫降低得慢；溫暖室內(nèi)的尸溫比寒冷室外的尸溫冷得要慢。因此，現(xiàn)在法醫(yī)學(xué)對(duì)死亡時(shí)間的鑒定是一個(gè)相對(duì)粗略的時(shí)間區(qū)間段判斷。

“基因表達(dá)法”為什么目前不靠譜

大概從十幾年前開始，中國(guó)法醫(yī)學(xué)界開始探討是否可以通過(guò)監(jiān)測(cè)人死后基因表達(dá)的變化獲得更精確的死亡時(shí)間，其中以華中科技大學(xué)同濟(jì)醫(yī)學(xué)院教授劉良和他的團(tuán)隊(duì)為代表?！缎∈蠊趋兰〖?xì)胞核DNA降解與死亡時(shí)間的關(guān)系》《運(yùn)用RNA降解規(guī)律構(gòu)建數(shù)學(xué)模型推斷死亡時(shí)間》《人體死后肝細(xì)胞DNA含量與死亡時(shí)間關(guān)系的研究》等研究成果都發(fā)表在雜志上。

但是，這些研究大多已停滯。業(yè)內(nèi)人士告訴科技日?qǐng)?bào)記者，這項(xiàng)研究后來(lái)進(jìn)展不大，有些關(guān)鍵問(wèn)題始終無(wú)法突破，個(gè)體差異和現(xiàn)實(shí)干擾因素等老問(wèn)題無(wú)法解決，更重要的是成果始終無(wú)法從實(shí)驗(yàn)室走向應(yīng)用。

因?yàn)閷?shí)驗(yàn)室環(huán)境是穩(wěn)定單一的，而真正發(fā)生的案件是非常復(fù)雜的，每一個(gè)細(xì)微的差別都會(huì)影響鑒定。何光龍認(rèn)為，用人死后基因表達(dá)的變化來(lái)確定死亡時(shí)間的離真正應(yīng)用還很遠(yuǎn)。

In the field of criminal investigation, the determination of the time of death is one of the most important clues of the case, and the related research around it has not ceased. But the reality is not as optimistic as we think. Experts say that the industry is still mostly using traditional methods, and the time of death is determined by gene expression. Although forensic experts have studied for many years, they still remain in laboratories, and there is still a long way to go for real applications.

There has been no perfect method

So far, the field of forensic science technology PMI, is mainly based on the body phenomenon, such as temperature, body, rigor mortis, stomach digestion and around the body, plant growth changes. Accurate inference of death time is a recognized problem in forensic science. At present, there is no "gold index" which is not affected by individual differences and postmortem changes, and can be applied to actual cases. He Guanglong, deputy director of the forensic pathology injury Technology Department of the Ministry of public security's physical evidence identification center, said.

From a professional point of view, the method of inferring the time of death based on the phenomenon of corpses is mostly related to statistics, and there are relevant formulas. However, what we are saying is that environmental factors such as temperature and humidity, physical and death causes of the dead will cause individual differences after death, which will affect the accuracy of the estimation of the time of death. For example, the body temperature changes to infer the early time of death in present case is widely used, but the change of the temperature change of the body temperature, clothing, status, environment and other factors. The corpse fat thin body temperature than the same environment decreased slowly; the body temperature warm indoor temperature. Cold outdoor cold slowly.  Therefore, the identification of the time of death by forensic medicine is a relatively rough time interval judgment.

Why "gene expression" is not reliable at present

Since about ten years ago, Chinese forensic science began to explore whether we could get more precise death time by monitoring the change of gene expression after death. Among them, Professor Liu Liang and his team from Tongji Medical College of Huazhong University of Science and Technology represented him. The relationship between the DNA degradation and the time of death in skeletal muscle of mice has been published in authoritative journals by using the mathematical model of RNA degradation rule to deduce the relationship between the time of death, the DNA content of postmortem hepatocytes and the time of death.

However, most of these studies have stagnated. Insiders told ScienceDaily Daily reporters that the research didn't progress very much, and some key problems could not be broken through. The old problems such as individual differences and realistic interference factors could not be solved, and more importantly, the results could never be applied from the laboratory to the application.

Because the laboratory environment is stable and single, and the real case is very complex, and every subtle difference will affect the identification. He Guanglong believes that the change in the expression of gene expression after death is far from the real application of the time of death.